Progesterone in Oil

What is Progesterone in Oil?

Progesterone in Oil is only administered intramuscularly.


Progesterone is a hormone that is needed to increase the receptivity of your endometrium for implantation of an embryo and is used as part of an assisted reproductive technology (ART). The hormone is a natural hormone and is safe to take during pregnancy (ignore any warnings that may be included with your prescription).


50 mg of Progesterone in Oil = 1cc


Preparation Of Progesterone In Oil:

  1. Wash your hands thoroughly and make sure that the surface you work on is clean.
  2. Use an alcohol swab to cleanse the rubber stoppers of the progesterone medication.
  3. With the needle pointing toward the ceiling, flick the side of the syringe to disperse the air bubbles and the air pocket at the top of the syringe, then gently push the plunger to eliminate any air until you expel one or two drops of liquid from the tip of the needle.
  4. Using the 3cc syringe with a 1½ inch needle, pull back on the plunger to the 1cc mark.
  5. Pierce the rubber stopper of the progesterone vial. Inject 1cc of air into the vial.
  6. Turn the vial upside down; making sure the tip of the needle is below the fluid level. Withdraw the dosage ordered. Because the progesterone is dispersed in oil, it will pull into the syringe more slowly than sterile water does as when you use your other fertility medications.
  7. Pull out the needle and replace the cap. Pull back on the plunger to clear the needle of any medication. Remove the needle from the syringe and administer according to your intramuscular administration directions.

Helpful hint:

Since the oil is thicker than water, this injection takes slightly longer to inject and the site may become sore after a few days. Discomfort can be minimized by applying moist heat (a wet washcloth warmed in the microwave works well) 5 minutes before and after giving the injection. You should move around and gently massage the area for a few minutes after administration.


Back to Medication